NOTORIOUS B.I.G
Known to many as Biggie, Notorious B.I.G was Pac's main enemy. Tupac first started dissing Biggie, and that made the Eastside/Westside beef. Tupac and Biggie were homeboys and were together in Thug Life. Pac always let Biggie come on in his concerts and made Biggie what he was. But when Tupac got shot, he blamed Biggie for setting him up. Biggie was signed with Puffy's (P Diddy) record compay Bad Boy Records. Bad Boy wanted Tupac to join but he refused. But he was going to do a song with Lil Shawn. He was shot 5 times and then went to prison after on a 4 years charge for rape which he didn't do. While he was in jail people were telling him it was some homies of Biggie that shot him. Also Biggie or Puffy never bothered to visit him. So he added all this up and came to the conclusion that Biggie and Puffy set him up. Along with Stretch, Lil Shawn and King Tut (who he knew as Nigel at the time). when he was released from prison he joined Death Row Records and started dissing Biggie. He also stared Westside (also known as Westcoast). He dissed Biggie and many more in songs like Fuck Em All, When We Ride On Our Enemies and Hit Em Up, the most controversial diss song in history. Notorious B.I.G died in May 1997.
P DIDDY
Originally known as Puff Daddy, P Diddy was nicknamed Puffy. he was one of Biggie's best friends and is the owner of Bad Boy Records. Tupac believed Puffy set him up as well with Biggie. Also there were rumours that Puffy ordered the 1996 shooting which was fatal to Tupac. But there is no proof of this. Tupac and co dissed Puffy a lot for being fake and getting rich off of other talents. Puffy already had beef with Suge Knight (CEO of Death Row).This created a feud between the two record companies, Death Row and Bad Boy.
MOBB DEEP
Mobb Deep are the only enemies of Tupac I dont like. They continued to diss Pac after he died. Tupac was okay with these two rappers (Prodigy and Havoc), but when he went to prison they took his Thug Life slogan and went round sayin it themselves. In an interview they said "Thug Life, we still livin it." This pissed Tuapc right off. So he threw disses out to them in songs like Hit Em Up and When We Ride On Our Enemies. One of them had sickle cells, a disease, and he dissed them saying one of them might have a seizure or heart attack.
NAS
Tupac and Nas had met up once and Pac told Nas not to get caught up in the East/West beef. Later Pac heard Nas' song The Message which was dissin fake thugs. Tupac thought Nas was talking about him. Also Nas kept talking about Thug Life, which was Pac's slogan. So Tupac dissed him in songs like Bomb First and Against All Odds on his The Don Killuminati album under the name Makaveli. Nas made peace with Tupac after he died and praised him on the song We Will Survive. Also Nas appeared on the Thugz Manion Remix on Pac's album Better Dayz.
LL COOL J
LL Cool J, which stood for Ladies Love Cool James (real name James Todd Smith), was one of the earlier rappers, who took rap to what it was when Tupac and Biggie were around. Tupac liked him at first and gave him respect in the song Old School. But for some reason they ended up with beef. It was after LL Cool J remixed Biggie's song Who Shot Ya, with I Shot Ya. Tupac thought LL was talking about the 1994 shooting and dissed him in the song Lil Homies (This is cut off the end of the Until The End Of Time version).
DR DRE
Real name Andre Young, Dr Dre was also signed to Death Row and recorded the song California Love with Pac. Dre created Death Row along with Suge Knight. Dr Dre discovered rapping talents like Snoop Dogg, and Daz Dillinger. But he relied too much on their success. He had only bought out the album The Chronic. This annoyed Tupac. And Dre didnt like Pac that much as he was jealous of his success. The final straw was when Dre failed to turn up at a court case with Snoop Dogg. Pac thought he was lazy and dissed him calling him gay. Dre left Deathrow and that pissed Pac off even more. He disses him in the songs Toss It Up featuring K-Ci & JoJo, Danny Boy and Aaron Hall, and To Live And Die In LA which he called "California Love part mutherfucking two. Without gay ass Dre". Dr Dre only hit back at Death Row (in Forgot About Dre ft Eminem) after Pac died. In a recent song (Shit Hits the Fan-Obie Trice featuring Dr Dre and Eminem from Obie's album Cheers) Dre praises Tupac saying (dissing Ja Rule) "Pussy you not Pac, I knew him. Pac was a real nigga, you just a fucking insult to him. It's too bad we had to fall out before he passed, cuz if he could see the shit he'd be whoopin yo ass." Dr Dre also made up with stars like Snoop Dogg and Nate Dogg.
CHINO XL
This all started when Chino XL said in his song Riot "I'm tryin not to get fucked like Tupac in jail (see Wendy Williams)." Tupac didn't consider Chino XL on his level but dissed him on the song Hit Em Up. "Chino XL, fuck you too." After Pac died Chino said in an interview that he liked Tupac's music and wished hed never had beef. Chino XL was shot in 2004 by a black man screaming "Thug Life!".
WENDY WILLIAMS
Tupac started dissing Wendy Williams when she claimed Tupac got raped in jail. He absolutey slaughtered her on the song Why U Turn On Me?
DELORIS TUCKER
Deloris Tucker was constantly trying to censor rap music saying it needed to be banned. Deloris was black herself so this pissed Tupac off. He dissed her on songs like How Do U Want It and Wonda Why They Call U Bytch. So Deloris Tucker waited until Tupac died then sued. I wonder why they call you bitch too? Money grabber.
THE FUGEES
Im not sure how this started but Tupac dissed The Fugees in the song When We Ride On Our Enemies. On the recent official 2 Pac mixtape: Rap Phenomenon 2, Wycleff Jean remixed baby Don't Cry and called it a "tribute to Tupac".
JAY Z
Real name Shawn Carter, Jay Z is the owner of Roc-A-Fella Records. This beef started after Jay Z appeared on Biggies song New Yorks Finest in which Pac was dissed. Pac dissed Jay in songs such as Bomb First, Fuck Friends and All Out.